FIG. 2.

Accumulation and biodistribution of naked PNA_TAR and its cell-penetrating peptide conjugates in mice organs and tissues: ¹²⁵I-labeled unconjugated or conjugated PNAs were dissolved in phosphate-buffered saline and given, in a single dose of 200 μl, to Balb/C mice by intraperitoneal injection (A) or oral gavage (B). At different points after this administration, the mice were euthanized and their organs and tissues individually collected and their accumulated radioactivity counted with a gamma counter. After that there was a steady decline in the activity in each organ and tissue.