Table 5.

Excretion Profile of PNA Conjugates Administered by Intraperitoneal Injection

	Naked PNATAR		PNATAR-Tat		PNATAR-Penetratin (S-S)
	% AA excreted in		% AA excreted in		% AA excreted in
åTime (hours)	Urine	Feces	Urine	Feces	Urine	Feces
4	9.5	1.24	4.8	0.8	28.8	0.74
8	0.72	0.52	1.9	1.9	7.37	1.16
12	0.21	0.11	1.17	1.17	7.28	1.59
16	0.1	0.03	0.21	0.10	0.99	0.36
20	0.02	0.02	0.16	0.01	0.21	0.04
24	0.04	0.01	0.03	0.02	0.28	0.03
48	0.01	0.06	0.05	0.01	0.81	0.24
72	0.20	0.10	0.40	0.17	0.43	0.18

Groups of three male Balb/C mice were given ¹²⁵I-labeled naked PNA or PNA conjugates and placed in separate polycarbonate cages lined with thick Whatman filter papers. Animals were transferred to fresh cages at an interval of 4 hours. The filter papers soaked in the urine were collected, cut into pieces, and counted for radioactivity. Feces were counted without further processing. Values are expressed as the percent of administered activity (%AA) excreted in urine or feces.