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A model for activation of mRNA decay by PMR1. In this model PMR1 present on polysomes as part of a large RNP complex is maintained in a latent form by a bound inhibitory protein IPA (inhibitor of PMRI activity). Estrogen (E) activates a signal transduction pathway resulting in post-translational modification of IPA (indicated here as phosphorylation, but that is only speculation), causing it to dissociate from PMR1 and activate cleavage of albumin mRNA within the complex.
