Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1968 Mar;47(3):427–435. doi: 10.1172/JCI105739

Plasma growth hormone concentration in corticosteroid-treated children

Helen G Morris 1, Jacqueline R Jorgensen 1, Shirley A Jenkins 1
PMCID: PMC297189  PMID: 5637133

Abstract

Endogenous plasma growth hormone concentrations were measured in 23 children who were receiving daily corticosteroid therapy and in 10 control asthmatic children who had not received steroids for at least 8 months. The growth hormone concentrations were similar in the two groups of patients both during the fasting state and after insulin-induced hypoglycemia. 12 children, who were studied while receiving a large dose of prednisone and again 2 wk after steroid withdrawal, also showed no change in growth hormone concentration in relation to corticosteroid therapy. These findings suggest that deficiency of growth hormone is not the major mechanism responsible for the dwarfism of corticosteroid-treated children.

Full text

PDF
430

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLODGETT F. M., BURGIN L., IEZZONI D., GRIBETZ D., TALBOT N. B. Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children. N Engl J Med. 1956 Apr 5;254(14):636–641. doi: 10.1056/NEJM195604052541402. [DOI] [PubMed] [Google Scholar]
  2. BROWN J. B., BULBROOK R. D., GREENWOOD F. C. An evaluation of a chemical method for the estimation of oestriol, oestrone and oestradiol-17 beta in human urine. J Endocrinol. 1957 Nov;16(1):41–48. doi: 10.1677/joe.0.0160041. [DOI] [PubMed] [Google Scholar]
  3. CORNBLATH M., PARKER M. L., REISNER S. H., FORBES A. E., DAUGHADAY W. H. SECRETION AND METABOLISM OF GROWTH HORMONE IN PREMATURE AND FULL-TERM INFANTS. J Clin Endocrinol Metab. 1965 Feb;25:209–218. doi: 10.1210/jcem-25-2-209. [DOI] [PubMed] [Google Scholar]
  4. FINGERHUT B., FERZOLA R., MARSH W. H. APPLICATION OF A FERROCYANIDE-PHOSPHOMOLYBDATE REACTION TO AN AUTOMATED DETERMINATION OF SERUM GLUCOSE. Clin Chim Acta. 1963 Nov;8:953–959. doi: 10.1016/0009-8981(63)90020-2. [DOI] [PubMed] [Google Scholar]
  5. FRANTZ A. G., RABKIN M. T. HUMAN GROWTH HORMONE. CLINICAL MEASUREMENT, RESPONSE TO HYPOGLYCEMIA AND SUPPRESSION BY CORTICOSTEROIDS. N Engl J Med. 1964 Dec 31;271:1375–1381. doi: 10.1056/NEJM196412312712701. [DOI] [PubMed] [Google Scholar]
  6. Frantz A. G., Rabkin M. T. Effects of estrogen and sex difference on secretion of human growth hormone. J Clin Endocrinol Metab. 1965 Nov;25(11):1470–1480. doi: 10.1210/jcem-25-11-1470. [DOI] [PubMed] [Google Scholar]
  7. GLICK S. M., ROTH J., YALOW R. S., BERSON S. A. IMMUNOASSAY OF HUMAN GROWTH HORMONE IN PLASMA. Nature. 1963 Aug 24;199:784–787. doi: 10.1038/199784a0. [DOI] [PubMed] [Google Scholar]
  8. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Greenwood F. C., Landon J., Stamp T. C. The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin. I. In control subjects. J Clin Invest. 1966 Apr;45(4):429–436. doi: 10.1172/JCI105357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HARTOG M., GAAFAR M. A., FRASER R. EFFECT OF CORTICOSTEROIDS ON SERUM GROWTH HORMONE. Lancet. 1964 Aug 22;2(7356):376–378. doi: 10.1016/s0140-6736(64)90389-7. [DOI] [PubMed] [Google Scholar]
  11. HARTOG M., GAAFAR M. A., MEISSER B., FRASER R. IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS. Br Med J. 1964 Nov 14;2(5419):1229–1232. doi: 10.1136/bmj.2.5419.1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hunter W. M., Greenwood F. C. A radio-immunoelectrophoretic assay for human growth hormone. Biochem J. 1964 Apr;91(1):43–56. doi: 10.1042/bj0910043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morris H. G., Jorgensen J. R., Elrick H., Goldsmith R. E. Metabolic effects of human growth hormone in corticosteroid-treated children. J Clin Invest. 1968 Mar;47(3):436–451. doi: 10.1172/JCI105740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. REISFELD R. A., HALLOWS B. G., WILLIAMS D. E., BRINK M. G., STEELMAN S. L. Purification of human growth hormone on "sephadex G-200". Nature. 1963 Mar 23;197:1206–1207. doi: 10.1038/1971206a0. [DOI] [PubMed] [Google Scholar]
  15. ROTH J., GLICK S. M., YALOW R. S., BERSON S. A. Secretion of human growth hormone: physiologic and experimental modification. Metabolism. 1963 Jul;12:577–579. [PubMed] [Google Scholar]
  16. Root A. W., Rosenfield R. L., Bongiovanni A. M., Eberlein W. R. The plasma growth hormone response to insulin-induced hypoglycemia in children with retardation of growth. Pediatrics. 1967 Jun;39(6):844–852. [PubMed] [Google Scholar]
  17. SMITHIES O. Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem J. 1955 Dec;61(4):629–641. doi: 10.1042/bj0610629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stimmler L., Brown G. A. Growth hormone secretion provoked by insulin-induced hypoglycaemia in children of short stature. Arch Dis Child. 1967 Jun;42(223):232–238. doi: 10.1136/adc.42.223.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. YALOW R. S., BERSON S. A. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960 Jul;39:1157–1175. doi: 10.1172/JCI104130. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES