Table 1. Outcome of antiviral epidemic measures with various diagnosis delays and coverages.
final symptomatic attack rate (%) | peak daily incidence (per 10,000) | |||||||||||
baseline | 24.5 | 109 | ||||||||||
intervention strategy | diagnosis delay | diagnosis coverage | diagnosis delay | diagnosis coverage | ||||||||
0 h | 24 h | 48 h | 10% | 50% | 90% | 0 h | 24 h | 48 h | 10% | 50% | 90% | |
T | 17.4 | 21.0 | 22.4 | 23.8 | 21.0 | 17.8 | 63 | 84 | 96 | 104 | 84 | 68 |
T+SC | 13.6 | 17.1 | 18.2 | 18.4 | 17.1 | 14.5 | 29 | 39 | 41 | 48 | 39 | 35 |
T+H | 12.2 | 16.5 | 18.4 | 22.9 | 16.5 | 11.1 | 33 | 56 | 69 | 95 | 56 | 30 |
T+H+SC | 8.7 | 13.0 | 15.0 | 17.6 | 13.0 | 7.8 | 16 | 27 | 31 | 43 | 27 | 15 |
T+H+E | 8.8 | 13.0 | 15.4 | 20.8 | 13.0 | 7.6 | 20 | 34 | 47 | 84 | 34 | 17 |
T+H+E+SC | 6.7 | 10.7 | 13.4 | 16.8 | 10.7 | 6.1 | 12 | 19 | 26 | 39 | 19 | 12 |
Final symptomatic attack rate (as % of population) and peak daily symptomatic incidence (per 10,000) are given for different intervention strategies, diagnosis delays and diagnosis coverages. Intervention strategies are abbreviated as follows: T – antiviral treatment of diagnosed cases, H – prophylaxis of household of diagnosed cases, E – prophylaxis of school or work contacts of diagnosed cases, SC – four weeks of school closure. Where diagnosis delay differs from 24 hours, diagnosis coverage is 50%; where diagnosis coverage differs from 50%, diagnosis delay is 24 hours.