Table 2.
List of genes in the p53-p21 pathway upregulated following Sp1 knockdown
| Probe Set ID | Gene Title | Gene Symbol | 48 hr post Sp1 knockdown | 72 hr post Sp1 knockdown | ||
|---|---|---|---|---|---|---|
| Fold change | Regulation | Fold change | Regulation | |||
| 220403_s_at | p53-regulated apoptosis-inducing protein 1 | P53AIP1 | 2.76 | up | - | No change |
| 202627_s_at | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | SERPINE1 (PAI) | 2.01 | up | 2.43 | up |
| 230330_at | protein phosphatase 1D magnesium-dependent, delta isoform | PPM1D (WIP-1) | 1.86 | up | - | No change |
| 204566_at | protein phosphatase 1D magnesium-dependent, delta isoform | PPM1D (WIP-1) | 1.72 | up | 1.52 | up |
| 202284_s_at | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDKN1A | 1.84 | up | 1.96 | up |
| 1555186_at | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDKN1A | - | No change | 1.25 | up |
| 203409_at | damage-specific DNA binding protein 2, 48kDa (p48 subunit) | DDB2 | 1.79 | up | - | No change |
| 204859_s_at | apoptotic peptidase activating factor 1 | APAF1 | 1.76 | up | - | No change |
| 218346_s_at | sestrin 1 | SESN1 | 1.74 | up | 1.56 | up |
| 204285_s_at | phorbol-12-myristate-13-acetate-induced protein 1 | PMAIP1 (NOXA) | 1.48 | up | 1.60 | up |
| 204286_s_at | phorbol-12-myristate-13-acetate-induced protein 1 | PMAIP1 (NOXA) | - | No change | 1.55 | up |
| 204781_s_at | Fas (TNF receptor superfamily, member 6) | FAS | 1.73 | up | 1.59 | up |
| 215719_x_at | Fas (TNF receptor superfamily, member 6) | FAS | 1.47 | up | 1.35 | up |
| 204780_s_at | Fas (TNF receptor superfamily, member 6) | FAS | 1.43 | up | 1.45 | up |
| 216252_x_at | Fas (TNF receptor superfamily, member 6) | FAS | 1.41 | up | - | No change |
| 208712_at | cyclin D1 | CCND1 | 1.46 | up | 1.39 | up |
| 208711_s_at | cyclin D1 | CCND1 | 1.34 | up | - | No change |
| 201700_at | cyclin D3 | CCND3 | 1.42 | up | - | No change |
| 222986_s_at | scotin | SCOTIN | 1.40 | up | - | No change |
| 242899_at | sestrin 3 | sesn3 | 1.38 | up | - | No change |
| 241015_at | sestrin3 | sesn3 | - | No change | 1.43 | down |
| 208796_s_at | cyclin G1 | CCNG1 | 1.38 | up | - | No change |
| 229415_at | cytochrome c, somatic | CYCS | 1.35 | up | - | No change |
| 211711_s_at | phosphatase and tensin homolog | PTEN | 1.25 | up | - | No change |
| 238075_at | CHK1 Checkpoint homolog (S.Pombe) | CHK1 | 1.23 | up | - | No change |
| 202981_x_at | seven in absentia homolog 1 (Drosophila) | SIAH1 | 1.20 | up | - | No change |
| 209260_at | stratifin | SFN (14-3-3σ) | 1.33 | up | - | No change |
| 33323_r_at | stratifin | SFN (14-3-3σ) | - | No change | 1.43 | up |
| 33322_i_at | stratifin | SFN (14-3-3σ) | - | No change | 1.35 | up |
| 213523_at | cyclin E1 | CCNE1 | - | No change | 1.34 | up |
| 204855_at | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | SERPINB5 (Maspin) | - | No change | 1.32 | up |
| 201110_s_at | thrombospondin 1 | THBS1 (TSP1) | - | No change | 1.32 | up |
| 211692_s_at | BCL2 binding component 3 | BBC3 (PUMA) | - | No change | 1.23 | up |