Table 3.
Regulatory factors involved in the coagulation cascade and lipid metabolism in zebrafish and mammalian obesity
| Coagulation cascade | Zebrafish | Rat | Mouse | Human | ||||
|---|---|---|---|---|---|---|---|---|
| Regulatory factor | p-value | Ranka | p-value | Ranka | p-value | Ranka | p-value | Ranka |
| APOH | 1.9E-08 | 1 | 8.4E-16 | 1 | 2.4E-12 | 2 | 9.1E-11 | 4 |
| IL-6 | 4.6E-05 | 3 | 6.5E-10 | 5 | 8.2E-09 | 7 | 4.5E-10 | 6 |
| IL-1β | 7.0E-05 | 6 | 1.2E-08 | 8 | 1.6E-07 | 16 | 8.4E-09 | 9 |
| Lipid metabolism | Zebrafish | Rat | Mouse | Human | ||||
| Regulatory factor | p-value | Ranka | p-value | Ranka | p-value | Ranka | p-value | Ranka |
| PPARα | 1.6E-10 | 1 | 1.1E-23 | 1 | 9.1E-19 | 1 | 6.9E-24 | 1 |
| PPARγ | 1.7E-10 | 2 | 1.7E-15 | 3 | 2.1E-14 | 2 | 1.1E-16 | 3 |
| NR1H3 | 1.0E-06 | 5 | 1.6E-15 | 2 | 2.7E-12 | 5 | 5.8E-17 | 2 |
| LEP | 1.8E-05 | 9 | 4.1E-10 | 13 | 3.7E-09 | 8 | 3.6E-12 | 10 |
| SREBF1 | 1.8E-03 | 36 | 2.8E-13 | 7 | 5.7E-10 | 7 | 9.9E-10 | 15 |
aRegulatory factors are ranked based on the p-value in each dataset.
Regulatory factors ranked within the top 15 in at least three datasets are shown in this table.