Figure 2.

Clustering, based on physiological function, of yeast genes required for maximal tolerance to acetic acid. The genes whose elimination was found to increase the susceptibility of S. cerevisiae BY4741 to acetic acid, according to the screening of yeast disruptome, were clustered using the MIPS functional catalogue and the enriched functional classes (those having a p-value below 0.01) were selected. The frequency in our dataset of acetic acid-tolerance genes (black bars), compared with the frequency of genes obtained when the whole yeast genome is used as an input (white bars), is also indicated.