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. 2010 Sep 15;30(37):12242–12251. doi: 10.1523/JNEUROSCI.1752-10.2010

Figure 8.

Figure 8.

Thiamine treatment attenuates the irradiation-associated loss of hippocampal Dcx+ cells. A, Representative Dcx staining of control and thiamine-treated hippocampi 8 d after x-irradiation. B, Quantification of hippocampal Dcx+ cells shows that thiamine treatment significantly reduced irradiation-induced Dcx+ cell loss. C, Thiamine treatment promotes no significant change in the irradiation-induced loss of proliferating IdU++CldU+ cells in hippocampus. D, The percentage of proliferating IdU++CldU+ cells that coexpress Dcx is markedly decreased after irradiation. Thiamine treatment significantly attenuates this decrease in the Dcx+ fraction of IdU++CldU+ cells. E, Microglial proliferation (fraction of IdU++CldU+ cells coexpressing the microglial marker Iba-1) is strongly increased by irradiation, and thiamine treatment does not change the number of proliferating microglia. The data are representative of five animals per each treatment group. Shown are mean ± SEM. #p < 0.001 compared with corresponding nonirradiated group; **p < 0.01, ***p < 0.001 compared with control-irradiated group.