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. Author manuscript; available in PMC: 2011 Nov 19.
Published in final edited form as: J Mol Biol. 2010 Sep 8;404(1):45–55. doi: 10.1016/j.jmb.2010.08.054

Table 2.

Ligand displacement Ki values

MC1R MC4R
Peptide Ki (nM) fold diff. Ki(nM) fold diff.
ASIP [chi(+1 +1 +1)] 0.70 ± 0.06 1 1.3 ± 0.3 1
AgRP [chi(−1 −1 −1)]a 47% n.a.d 11 ± 1 8.5
chi(−1 −1 0)a 26% n.a.d 6.1 ± 0.5 4.7
chi(+1 +1 0) 23 ± 3 33 0.90 ± 0.19 0.69
chi(−1 +1 0)b 870 ± 12 1242 5.4 ± 0.3 4.2
chi(+1 −1 0)c n.d. n.d.
chi(+1 +1 −1) 4.8 ± 0.3 6.8 1.1 ± 0.2 0.85
chi(−1 −1 +1) 32 ± 3.6 46 1.5 ± 0.3 1.1
chi(+1 −1 +1) 4.9 ± 1.1 7.0 2.1 ± 0.3 1.6
chi(+1 +1 +0.5) 0.44 ± 0.03 0.63 0.21 ± 0.04 0.16
a

Data from Jackson et al.20 Note that MC4R data are IC50 values and may therefore exceed the true Ki.

b

Data are from Jackson et al.25 Values at MC1R and MC4R are IC50s.

c

not determined

d

not applicable