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EC50 values for inhibition of NDP-MSH stimulated cAMP production
| MC1R | MC4R | |
|---|---|---|
| Peptide | EC50 (nM) | EC50 (nM) |
| no ligand | 0.25 ± 0.04 | 0.79 ± 0.01 |
| ASIP [chi(+1 +1 +1)] | 0.83 ± 0.02 | 6.4 ± 2.6 |
| AgRP [chi(−1 −1 −1)] | no binding | 17 ± 3 |
| chi(−1 −1 0) | no binding | 13 ± 3 |
| chi(+1 +1 0) | agonist | 20 ± 3 |
| chi(−1 +1 0) | agonist | 1.4 ± 0.4 |
| chi(+1 −1 0) | agonist | 56 ± 7 |
| chi(+1 +1 −1) | no shift | 11 ± 2 |
| chi(−1 −1 +1) | 0.42 ± 0.06 | 14 ± 2 |
| chi(+1 −1 +1) | 1.1 ± 0.1 | 19 ± 5 |
| chi(+1 +1 +0.5) | 3.5 ± 0.7 | 61 ± 8 |
