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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Pain. 2010 Sep 15;151(3):703–710. doi: 10.1016/j.pain.2010.08.037

Figure 4.

Figure 4

Lack of tolerance to repeated administration of WIN2 over 8 days. The graph compares the effect on the VMRth of a single treatment of WIN2 (3 mg/kg) with multiple treatments in ENDO rats. In the multiple group, WIN2 was given three times at four-day intervals. No values between single-and multiply-dosed groups differed significantly; i.e., pre drug (P = 0.775), post-drug (P = 0.437), or the change in VMRth from pre to post drug (P = 0.711, not shown on graph); Students t-tests. Data are shown as means ± s.e.m.