Table 1.
Examples of Non-collagen ECM and non-ECM substrates regulated by MMPs 30, 81–98
| Substrate | MMP | Regulated Activity |
|---|---|---|
| Aggrecan | -3, -8, -14 | Inflammation |
| CD44 (hyaluronan receptor) | -14 | Cell Migration |
| Complement C1q | -1, -2, -3, -9 | Neutrophil superoxide production |
| Connexin 43 | -7 | Myocyte Electrical Conduction |
| Fibrinogen | -2, -3, -7, -9, -14 | Myocyte Contractility |
| Fibronectin | -7, -9 | Gene Expression |
| Fibroblast Growth Factor Receptor 1 | -2 | Mitogenesis and Angiogenesis |
| Galectin-3 | -2, -9 | Cell Proliferation and Phagocytosis |
| Interleukin-1β | -1, -2, -3, -9 | Inflammation |
| Insulin-like Growth Factor Binding Protein-3 | -1, -2, -3 | Cell Proliferation |
| Latent TGF-β1, -β2, -β3 | -2, -9 | Cell Differentiation and Angiogenesis |
| Laminin | -2, -3, -9, -14 | Cell Migration |
| Monocyte Chemotactic Proteins-1, -2, -4 | -1, -3 | Cell Chemotaxis |
| Monocyte Chemotactic Protein-3 | -2, -14 | Cell Chemotaxis |
| Myosin Light Chain 1 | -2 | Contractile Dysfunction |
| Osteopontin | -2, -3, -7, -9 | Cell Adhesion |
| Serpina 1d | -9 | Protease Inhibition |
| Tenascin-C | -7, -9 | MMP Expression |
| Thrombospondin-1 | -9 | Angiogenesis |
| Tumor Necrosis Factor-α | -1, -2, -3, -7, -9 | Inflammation |
| Troponin-I | -2 | Cardiac Mechanical Function |