Table 3.
Gene ontology classes identified by genes from Table 2.
| GO identifier | Group size | Gene symbol(s) | GO term | No. of Hits |
P | |
|---|---|---|---|---|---|---|
| Obsb | Expb | |||||
| GO:0021942 | 2 | CTNNA2, DAB1 | Radial glia guided migration of Purkinje cell | 2 | 1 | 0.004625 |
| GO:0021535 | 4 | CTNNA2, DAB1 | Cell migration in hindbrain | 2 | 1 | 0.005527 |
| GO:0043005 | 194 | CDH13, CTNNA2, DNM3, GABBR2, PARK2, SLC1A2 | Neuron projection | 6 | 1 | 0.005752 |
| GO:0007268 | 304 | CTNNA2, GABBR2, GRIK2, KCNIP1, KIF1B, PARK2, SLC1A2 | Synaptic transmission | 7 | 1 | 0.006198 |
| GO:0007399 | 912 | CTNNA2, DAB1, DLC1, DNM3, FGF12, PARK2, SEMA3A, SLC1A2, SLIT3, SOX5 | Nervous system development | 11 | 3 | 0.006541 |
| GO:0021932 | 3 | CTNNA2, DAB1 | Hindbrain radial glia guided cell migration | 2 | 1 | 0.006923 |
| GO:0007267 | 609 | CTNNA2, FGF12, GABBR2, GRIK2, KCNIP1, KIF1B, PARK2, SLC1A2, TP63 | Cell–cell signaling | 9 | 2 | 0.007025 |
| GO:0030054 | 490 | CTNNA2, DLC1, GABBR2, GRIK2, LMO7, MAGI2, NRAP, PSD3 | Cell junction | 8 | 2 | 0.007113 |
| GO:0007417 | 351 | CTNNA2, DAB1, DLC1, PARK2, SLC1A2, SLIT3, SOX5 | Central nervous system development | 7 | 2 | 0.007605 |
| GO:0042805 | 5 | LMO7, NRAP | Actinin binding | 2 | 1 | 0.007661 |
| GO:0019226 | 349 | CTNNA2, GABBR2, GRIK2, KCNIP1, KIF1B, PARK2, SLC1A2 | Transmission of nerve impulse | 7 | 2 | 0.008389 |
| GO:0051674 | 520 | ASTN1, CDH13, CTNNA2, DAB1, DLC1, PRKCA, SEMA3A, SLIT3 | Localization of cell | 8 | 2 | 0.009009 |
| GO:0043395 | 8 | GPC5, GPC6 | Heparan sulfate proteoglycan binding | 2 | 1 | 0.009135 |
| GO:0006928 | 520 | ASTN1, CDH13, CTNNA2, DAB1, DLC1, PRKCA, SEMA3A, SLIT3 | Cell motion | 8 | 2 | 0.009759 |
| GO:0010259 | 10 | SLC1A2, TP63 | Multicellular organismal aging | 2 | 1 | 0.010234 |
| GO:0043394 | 10 | GPC5, GPC6 | Proteoglycan binding | 2 | 1 | 0.010773 |
| GO:0044456 | 197 | DNM3, GABBR2, GRIK2, PSD3, SLC1A2 | Synapse part | 5 | 1 | 0.011012 |
| GO:0045202 | 294 | DNM3, GABBR2, GRIK2, MAGI2, PSD3, SLC1A2 | Synapse | 6 | 1 | 0.011148 |
| GO:0010646 | 866 | CDH13, DLC1, GRIK2, PARK2, PRKCA, PSD3, RAPGEF4, RGS6, TCF7L1, TP63 | Regulation of cell communication | 10 | 3 | 0.011326 |
| GO:0007154 | 4,037 | CDH13, CTNNA2, DAB1, DGKB, DKFZp434B1272, DLC1, FGF12, GABBR2, GRIK2, KCNIP1 | Cell communication | 25 | 14 | 0.011507 |
| GO:0005515 | 7,814 | A2BP1, ASTN1, CASP7, CDH13, CTNNA2, DAB1, DGKB, DIP2C, DLC1, DNM36 | Protein binding | 38 | 26 | 0.01181 |
| GO:0043616 | 12 | CDH13, TP63 | Keratinocyte proliferation | 2 | 1 | 0.012998 |
| GO:0001964 | 12 | CTNNA2, PARK2 | Startle response | 2 | 1 | 0.013588 |
| GO:0030902 | 52 | CTNNA2, DAB1, DLC1 | Hindbrain development | 3 | 1 | 0.01365 |
| GO:0016477 | 336 | ASTN1, CDH13, CTNNA2, DAB1, DLC1, PRKCA | Cell migration | 6 | 2 | 0.01407 |
| GO:0005912 | 139 | CTNNA2, DLC1, LMO7, NRAP | Adherens junction | 4 | 1 | 0.016601 |
| GO:0040011 | 495 | ASTN1, CDH13, CTNNA2, DAB1, DLC1, PRKCA, SEMA3A | Locomotion | 7 | 2 | 0.017088 |
| GO:0050927 | 15 | CDH13, PRKCA | Positive regulation of positive chemotaxis | 2 | 1 | 0.017505 |
| GO:0045296 | 15 | CDH13, CTNNA2 | Cadherin binding | 2 | 1 | 0.018178 |
| GO:0048870 | 370 | ASTN1, CDH13, CTNNA2, DAB1, DLC1, PRKCA | Cell motility | 6 | 2 | 0.018515 |
| GO:0050926 | 15 | CDH13, PRKCA | Regulation of positive chemotaxis | 2 | 1 | 0.018905 |
| GO:0042995 | 514 | CDH13, CTNNA2, DNM3, GABBR2, PARK2, SLC1A2, SLC22A5 | Cell projection | 7 | 2 | 0.019186 |
| GO:0007626 | 257 | CDH13, NPAS3, PARK2, PRKCA, SEMA3A | Locomotory behavior | 5 | 1 | 0.020432 |
| GO:0003674 | 15,439 | A2BP1, ASTN1, BICC1, CASP7, CDH13, COL22A1, CTNNA2, DAB1, DGKB, DIP2C | Cell adhesion | 57 | 51 | 0.02068 |
| GO:0050918 | 18 | CDH13, PRKCA | Positive chemotaxis | 2 | 1 | 0.020739 |
| GO:0005626 | 685 | HMOX2, MAGI2, PDE4D, PRKCA, PSD3, RAPGEF4, SLC14A2, SLC1A2 | Insoluble fraction | 8 | 3 | 0.020892 |
| GO:0070161 | 157 | CTNNA2, DLC1, LMO7, NRAP | Anchoring junction | 4 | 1 | 0.021548 |
| GO:0051179 | 3,205 | A2BP1, ASTN1, CDH13, CTNNA2, DAB1, DLC1, DNM3, GRIK2, KCNIP1, KIF1B | Localization | 20 | 11 | 0.024066 |
| GO:0021575 | 21 | DAB1, DLC1 | Hindbrain morphogenesis | 2 | 1 | 0.025229 |
| GO:0007610 | 417 | CDH13, NPAS3, PARK2, PRKCA, SEMA3A, SLC1A2 | Behavior | 6 | 2 | 0.026079 |
| GO:0016337 | 284 | ASTN1, CDH13, CTNNA2, DAB1, LMO7 | Cell–cell adhesion | 5 | 1 | 0.02663 |
| GO:0043197 | 23 | DNM3, SLC1A2 | Dendritic spine | 2 | 1 | 0.027998 |
| GO:0044459 | 2,123 | CDH13, CTNNA2, DLC1, GABBR2, GPC5, GPC6, GRIK2, LMO7, MAGI2, NRAP | Plasma membrane part | 15 | 7 | 0.028616 |
| GO:0022610 | 768 | ASTN1, CDH13, COL22A1, CTNNA2, DAB1, DLC1, LMO7, MYBPC1 | Biological adhesion | 8 | 3 | 0.028908 |
| GO:0005913 | 24 | LMO7, NRAP | Cell–cell adherens junction | 2 | 1 | 0.029029 |
| GO:0007155 | 767 | ASTN1, CDH13, COL22A1, CTNNA2, DAB1, DLC1, LMO7, MYBPC1 | Cell adhesion | 8 | 3 | 0.029264 |
| GO:0040017 | 25 | CDH13, PRKCA | Positive regulation of locomotion | 2 | 1 | 0.029388 |
| GO:0050920 | 26 | CDH13, PRKCA | Regulation of chemotaxis | 2 | 1 | 0.029785 |
a
Genes identified by data from the current study and at least two additional 500,000, 600,000 or 1,000,000 SNP GWA studies of smoking cessation success were subjected to BioBase functional enrichment analyses. Columns list the GO identifier, number of genes supporting the GO class, list of the first several genes that support the class, definition of the GO term, number of genes observed, number of genes expected by chance and FDR-corrected P value. The 48 GO terms with the lowest FDR-corrected P values are listed.
b
Obs, observed; Exp, expected by chance.