Table 2.
Association of the VDR rs2228570 SNP with invasive ovarian carcinoma risk among non-Hispanic white women by study
| Heterozygotes and rare allele homozygotes* | Log-additive model | Dominant model* | ||||||
|---|---|---|---|---|---|---|---|---|
| Study | CT OR (95% CI)† |
TT OR (95% CI)† |
P (2 d.f.) | Per allele OR (95% CI)† |
P for trend (1 d.f.) |
Any T allele OR (95% CI)† |
P (1 d.f.) | |
| HAW | 2.20 (1.05–4.63) | 2.15 (0.80–5.76) | 0.10 | 1.55 (0.98–2.47) | 0.06 | 2.19 (1.07–4.47) | 0.03 | |
| MALOVA | 1.14 (0.90–1.46) | 1.04 (0.73–1.47) | 0.54 | 1.05 (0.89–1.23) | 0.57 | 1.12 (0.89–1.41) | 0.34 | |
| SEARCH | 1.24 (1.02–1.52) | 1.02 (0.76–1.35) | 0.08 | 1.06 (0.93–1.21) | 0.41 | 1.18 (0.98–1.21) | 0.08 | |
| GEOCS | 1.01 (0.71–1.43) | 1.61 (0.99–2.62) | 0.12 | 1.21 (0.96–1.52) | 0.11 | 1.13 (0.81–1.58) | 0.46 | |
| UKOPS | 0.82 (0.59–1.14) | 1.26 (0.79–2.01) | 0.15 | 1.04 (0.83–1.30) | 0.75 | 0.90 (0.66–1.23) | 0.51 | |
| All | 1.13 (1.00–1.29) | 1.16 (0.97–1.39) | 0.10 | 1.09 (1.01–1.19) | 0.04 | 1.14 (1.01–1.28) | 0.03 | |
| All excluding HAW | 1.11 (0.97–1.26) | 1.14 (0.95–1.37) | 0.21 | 1.09 (1.00–1.19) | 0.06 | 1.11 (0.99–1.26) | 0.08 | |
| P‡ for heterogeneity | 0.14 | 0.19 | 0.39 | 0.30 | ||||
| HAW (initial published study including 15 borderline malignancy and 56 invasive cases) 19 |
2.45 (1.25–4.81) | 2.06 (0.82–5.21) | 0.03 | 1.56 (1.01–3.41) | 0.04 | 2.36 (1.23–4.53) | 0.01 | |
*
CC genotype was used as the reference category.
†
Odds ratios (OR) and 95% confidence intervals (CI) from the unconditional logistic regression models adjusted for age, menopausal status, and, in combined analyses, by study.
‡
P for heterogeneity of the association of the rs2228570 SNP with risk by study was estimated using a Wald test of the genotype-study interaction term.
Note: statistically significant associations are presented in bold font (P<0.05).