Fig 1.

Impaired frequency facilitation in PS cDKO mice. (a) Reduction of PS1 in cortical lysates of PS cDKO mice at 4 weeks of age. (b–c) Representative traces from 5-week-old control and PS cDKO mice at 1 and 20 Hz stimulation frequency, respectively. Averaged responses to stimulus trains of 1 and 20 Hz stimulations recorded from control and PS cDKO mice. Values of EPSC amplitude were normalized to the amplitude of first EPSC in stimulation trains. (d) Summary graph comparing frequency dependence of synaptic facilitation in 5-week-old PS cDKO mice. (e) Summary graph comparing frequency dependence of synaptic facilitation in 4-week-old PS cDKO mice. The values in parentheses indicate the number of hippocampal neurons (left) and the number of mice (right) used in each experiment. ***p < 0.001.