Table 4.

Biochemical parameters and surrogate markers of hepatic encephalopathy during follow up of a single representative patient who initially presented with cholestatic decompensation of alcoholic liver cirrhosis three years after initial diagnosis. At the time of presentation, portal hypertension with hepato-splenomegaly and oesophageal varices, as well as grade II hepatic encephalopathy were diagnosed. During follow up after three months hepatic encephalopathy had deteriorated despite apparent improvement in cholestasis. In the 5 month, this patient received a liver transplant and was then re-assessed for hepatic encephalopathy at day 26 after surgery

	Month 1 presentation with decompensated cirrhosis	Month 3 decompensation of hepatic encephalopathy	Month 6 26 days after liver transplantation
Creatinine (0.67–1.17 mg/dl)	0.64 mg/dl	0.9 mg/dl	1.1 mg/dl
Prothrombin time (70–130%)	49%	36%	90%
C-reactive protein (0–0.7 mg/dl)	2.49 mg/dl	3.55 mg/dl	1.1 mg/dl
Bilirubin (0–1.28 mg/dl)	36.26 mg/dl	24.07 mg/dl	1.08 mg/dl
MELD score	18.05	21.09	8.07
Median critical flicker frequency	33.9 Hz	45.75 Hz	41.65 Hz
Psychometric test performance	−9	−17	−4
Median saccadic latency	352.5 ms	462.5 ms	271 ms