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. 2010 May 3;39(5):1345–1359. doi: 10.1093/ije/dyq063

Table 1.

Combined HRs for the relationship between baseline fibrinogen (g/l) and CHD risk, adjusted for a linear effect of age at baseline in each study separately

Method HR (95% CI) Log HR, Inline graphic (SE) Heterogeneity
Between-study variance Inline graphic P-value I2 (95% CI)
Untransformed fibrinogen: log HRs per 1 g/l increase
    Random-effects meta-analysis 1.57 (1.47–1.67) 0.450 (0.033) 0.018 <0.0001 64% (48, 76)
    Fixed-effects meta-analysis 1.52 (1.47–1.57) 0.419 (0.018) NA <0.0001 NA
Transformed fibrinogen: log HRs per SD increase—random-effects meta-analysis
    Untransformed fibrinogen 1.34 (1.29–1.40) 0.294 (0.022) 0.008 <0.0001 64% (48, 76)
    Log fibrinogen 1.38 (1.32–1.45) 0.325 (0.025) 0.010 <0.0001 65% (48, 76)
    Study-specific SD score fibrinogen 1.34 (1.29–1.40) 0.292 (0.021) 0.007 <0.0001 63% (45, 75)
    Study-specific SD score log fibrinogen 1.37 (1.31–1.44) 0.316 (0.024) 0.009 <0.0001 64% (47, 76)
Untransformed fibrinogen
    Quadratic term for fibrinogen 0.96 (0.91–1.01) −0.045 (0.027) 0.007 0.013 40% (7, 61)

NA: not applicable; SE: standard error.