Table 2.
Combined HRs for CHD per 1 g/l increase in baseline fibrinogen: random-effects meta-analysis adjusting for baseline confounding variables
| With adjustment for | HR (95% CI) | Log HR  (SE) |
 |
Heterogeneity |
||
|---|---|---|---|---|---|---|
Between-study variance 
|
P-value | I2 (95% CI) | ||||
| Age | 1.57 (1.47–1.67) | 0.450 (0.033) | 181 | 0.018 | <0.0001 | 64% (48, 76) |
| Age as 5-year age bands | 1.57 (1.47–1.68) | 0.451 (0.033) | 183 | 0.018 | <0.0001 | 64% (48, 76) |
| Stratification by 5-year age bands | 1.57 (1.47–1.68) | 0.451 (0.033) | 182 | 0.018 | <0.0001 | 64% (48, 76) |
| Age sex × age | 1.57 (1.47–1.68) | 0.450 (0.034) | 180 | 0.018 | <0.0001 | 65% (48, 76) |
| Age age2 | 1.56 (1.46–1.67) | 0.447 (0.033) | 179 | 0.018 | <0.0001 | 64% (48, 76) |
| Age age2 sex × age sex × age2 | 1.57 (1.47–1.67) | 0.448 (0.034) | 177 | 0.019 | <0.0001 | 65% (49, 76) |
| Age smoking tchol sbp bmia | 1.38 (1.31–1.45) | 0.320 (0.026) | 156 | 0.006 | 0.028 | 35% (0, 58) |
SE: standard error.
aSmoking coded as current vs other; tchol: total cholesterol; sbp: systolic blood pressure; bmi: body mass index.