Fig. 3.

The effects of adenovirus-mediated overexpression of TRB3 on insulin, PDX-1 and MafA mRNA expression. Northern blot analysis of insulin, PDX-1 and MafA mRNA expression in INS-1 cells infected with adenovirus encoding TRB3 (Ad-TRB3). INS-1 cells were infected with the indicated doses of Ad-TRB3 or Ad-LacZ for 24 hours. 18S rRNA levels were analyzed as an internal control. Data in the bar graph are the mean ± SEM of three independent measurements. ^aP < 0.01 and ^bP < 0.001 compared to control.