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Kinetic parameters for HNE metabolism.
| Isoform | Treatment | KM (μM) | Vmax (μmol min−1 mg−1) | kcat (s−1) | Catalytic efficiency (kcat/KM, s−1 mM−1) |
|---|---|---|---|---|---|
| GST A1-1 | Control | 43 ± 25 | 14 ± 2 | 12 ± 2 | 270 ± 170 |
| +HNE | 24 ± 14 | 10 ± 2 | 9 ± 1 | 400 ± 200 | |
| GST A4-4 | Control | 7 ± 6 | 44 ± 7 | 37 ± 6 | 5000 ± 4500 |
| +HNE | 14 ± 8 | 28 ± 4 | 24 ± 3 | 1700 ± 1000 | |
| GST P1-1 | Control | 80 ± 10 | 21 ± 1 | 16 ± 1 | 200 ± 30 |
| +HNE | 14 ± 8 | 0.21 ± 0.03 | 0.16 ± 0.02 | 11 ± 6 |
