Table 1.

Comparison between the CD8 T cell immune response during HIV-1 infection and an efficient immune response that should be induced by a protective vaccine.

CD8 T cell response characteristics	HIV-1 infection	Ideal Vaccine
Magnitude	Not associated to protection	Moderate or High
Breadth	Narrow/escape mutations	Broad and cross reactive
Avidity	Moderate/low	High
Functionality	Mono-functional responses	Polyfunctional responses
Proliferation	Impaired	Sustained
Memory	Impaired	Sustained
Timing of homing	Too late	Early