Table 1.
CD8 T cell response characteristics | HIV-1 infection | Ideal Vaccine |
---|---|---|
Magnitude | Not associated to protection | Moderate or High |
Breadth | Narrow/escape mutations | Broad and cross reactive |
Avidity | Moderate/low | High |
Functionality | Mono-functional responses | Polyfunctional responses |
Proliferation | Impaired | Sustained |
Memory | Impaired | Sustained |
Timing of homing | Too late | Early |