Table 2.

Recommendations regarding indications for treatment in CLL

	General practice*	Clinical trial
Treat with Rai stage 0	No†	RQ
Treat with Binet stage A	No†	RQ
Treat with Binet stage B or Rai stage I or II	Possible†	Possible†
Treat with Binet stage C or Rai stage III or IV	Yes	Yes
Treatment of active/progressive disease	Yes	Yes
Treat without active/progressive disease	No	RQ

No indicates not generally indicated; RQ, research question.

^*General practice is defined as the use of accepted treatment options for a patient with CLL not enrolled in a clinical trial.

^†Treatment is indicated, if the disease is active as defined in “Indications for treatment.”