Table III.
Summary of dose-effectiveness study in canine renal transplantation
| Latest biochemistry‡ |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Treatment | Survival days* |
Histologic severity of graft rejection † |
Creatinine (mg/dl) |
AST (IU/L) |
Total bilirubin (mg/dl) |
Glucose (mg/dl) |
FK blood level§ (ng/ml) |
|||
| 0 | 1 | 2 | 3 | ||||||||
| 1 | Untreated control |
13.0 ± 4.1 | 0 | 0 | 0 | 6/6 | 11.3 ± 3.1 |
35 ± 15 | 0.2 ± 0.2 | 105 ± 66 | — |
| 2 | FK, 0.5 mg/kg/day |
33.7 ± 23.9 | 0 | 1/5 | 2/5 | 2/5 | 7.7 ± 5.3 | 79 ± 47 | 0.4 ± 0.3 | 143 ± 32 | 0.44 ± 0.57 |
| 3 | FK, 1.0 mg/kg/day |
31.0 ± 18.4 | 1/6 | 0 | 3/6 | 2/6 | 2.8 ± 1.8 | 26 ± 6 | 0.4 ± 0.4 | 128 ± 30 | 0.68 ± 0.25 |
| 4 | FK, 1.5 mg/kg/day |
61.0 ± 33.6 | 1/3 | 1/3 | 0 | 1/3 | 3.0 ± 3.0 | 37 ± 17 | 0.9 ± 0.7 | 98 ± 29 | 0.40 ± 0.41 |
| 5 | FK, 2.0 mg/kg/day |
32.1 ± 33.9 | 5/5 | 0 | 0 | 0 | 1.4 ± 0.5 | 55 ± 28 | 1.2 ± 1.4 | 79 ± 37 | 3.92 ± 4.01 |
Legend: AST, Aspartate aminotransferase.
*
Used 90 days as a ceiling of calculation.
†
Grafts from animals that lived for more than 90 days are excluded, 0 (none), 1 (mild), 2 (moderate), and 3 (severe).
‡
Values from the latest measurement or at the ninetieth day.
§
By enzyme immunoassay with monoclonal antibody.