Table 3.
—Correlations Between IL-17A/F, Granulocytic Inflammation, and Lung Function in Asthma
Characteristic | IL-17A | IL-17F |
Neutrophils/mm2 submucosa | rs = −0.05, P = .8 | rs = 0.32, P = .078 |
Sputum neutrophils (%) | rs = −0.43, P = .03 | rs = −0.15, P = .45 |
Eosinophils/mm2 submucosa | rs = 0.2, P = .3 | rs = 0.50, P = .005 |
Sputum eosinophils, % | rs = 0.09, P = .7 | rs = 0.08, P = .7 |
FEV1, % predicted | rs = 0.38, P = .04 | rs = −0.06, P = .8 |
FEV1/FVC, % | rs = 0.35, P = .06 | rs = −0.17, P = .39 |
Methacholine PC20FEV1 | rs = −0.17, P = .5 | rs = −0.25, P = .25 |
rs = Spearman rank correlation coefficient. See Table 1 legend for expansion of the other abbreviation.