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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Exp Hematol. 2010 Jul 1;38(10):957–967.e1. doi: 10.1016/j.exphem.2010.06.011

Figure 5. The allo-graft response induced by MSC administration was dependent upon the degree of antigenic mismatch between donor and host.

Figure 5

Flow cytometric analysis was used to quantify levels of circulating CD8+ve, CD16+ve, and CD8+ve/CD16+ve cells one week prior to intracranial MSC administration (−7) and at 14 and 30 days post-transplantation. A) Fold change in circulating levels of lymphocyte subpopulations at 14 days post-transplant vs. pre-surgical levels. B-D) Changes in CD8+ve (B), CD16+ve (C), and CD8+ve/CD16+ve (D) levels in peripheral blood as a function of time post MSC administration. Statistical analyses were performed on test subjects grouped according to their degree of antigenic mismatch to the donor MSCs (A→A: HM56, HM66, HP06, HP07; A→B,DBR: HM67, HM72, HN91; A8→A8, HP32; A8→NA, HR86, HV88). *,p<0.05.