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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Exp Hematol. 2010 Jul 1;38(10):957–967.e1. doi: 10.1016/j.exphem.2010.06.011

Figure 7. Lack of in vivo sensitization of recipient PBMNCs to donor MSCs upon rechallenge in vitro.

Figure 7

PBMNCs isolated from peripheral blood of the indicated transplant recipients or shams at 6 months post-transplant were incubated at different ratios with donor MSCs (A), MSCs derived from an unrelated rhesus macaque (B), or human MSCs (C) and the amount of cytosolic lactate dehydrogenase (LDH) released into the media was quantified by ELISA. Cyto-toxicity was determined as the percentage increase over controls, which consisted of target and effector cell populations incubated in media alone without stimulation.