Figure 3.

Orthogonal views of CoMFA contour maps for the affinity of 6-benzyl-substituted β-carbolines at the α₁β₃γ₂ BzR.

Orthogonal view of CoMFA contour maps for the α₁β₃γ₂ receptor subtype with 6-benzyl-substituted β-carbolines modeled by Huang.⁶⁰ Green contours represent areas of positive steric interaction at a contribution level of 85%, which would result in reduced binding affinity. Blue contours represent areas of positive charge interaction at a level of 85%, which would increase the affinity of a ligand.