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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2010 Sep 29;18(21):7548–7564. doi: 10.1016/j.bmc.2010.08.049

Table 2b.

Affinities (Ki=nM) of Ether-substituted β-carbolines at αxβ3γ2(x=1–3,5,6) receptor subtypes

Ligands α1 α2 α3 α5 α6
graphic file with name nihms243911t16.jpg
34 		350.2 3000 3000 3000 10000
graphic file with name nihms243911t17.jpg
35 		830 3000 3000 10000 10000
graphic file with name nihms243911t18.jpg
36 		36.9 194 245 1000 1000
graphic file with name nihms243911t19.jpg
37 		24.9 123.6 139.2 1000 10000
graphic file with name nihms243911t20.jpg
38 		245 818 859 10000 10000
graphic file with name nihms243911t21.jpg
2 		5.3 52.3 68.8 591 1000
graphic file with name nihms243911t22.jpg
39 		6.43 25.1 28.2 826 1000

The affinity of compounds at GABAA/BzR recombinant subtypes was measured by competition for [3H]flunitrazepam binding to HEK cell membranes expressing human receptors of composition α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2.119 Data represent the average of at least three determinations with a SEM of ±5%.