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. 2010 Oct 27;30(43):14299–14304. doi: 10.1523/JNEUROSCI.3383-10.2010

Figure 3.

Figure 3.

Chronic diazepam administration reduces amyloid plaques and increases intraneuronal Aβ42 immunofluorescence. A, Quantification of cortical plaque number demonstrated a 32 ± 12% decrease in diazepam-treated (Tg+diazepam) compared with untreated Tg19959 (Tg) mice (n = 5; p < 0.01). Scale bar, 500 μm. B, Quantification of hippocampal plaque number demonstrated a 20 ± 9% decrease in plaques in diazepam-treated compared with untreated Tg19959 mice (n = 5, p < 0.05). Scale bar, 500 μm. C, Confocal microscopy showing intraneuronal Aβ42 immunofluorescence in Tg19959 hippocampus. Diazepam-treated Tg19959 mice show 41 ± 10% higher levels of intraneuronal Aβ42 immunoreactivity compared with untreated Tg19959 mice (n = 5; p < 0.01). Scale bar, 75 μm.