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CU-NP increases cGMP concentrations in myocytes. (A) Time- and concentration-dependent increase in cGMP concentrations in neonatal cardiomyocytes after treatment with increasing concentrations of CU-NP. (B) cGMP levels after treatment with CU-NP (1, 10, and 100 nM), ANP or CNP (100 nM for both) for 24 h. Values indicate means ± SEM and indicate fold increase. n = 8. *P < 0.05 from untreated cells. Ctl, control.
