Figure 2.

The proportion of expression–trait association results with population-based P-values <0.001 are plotted against distance from transcript boundaries for SNP within 1 Mb of transcript (6.86 million association tests). SNP distances were rounded up to the nearest kilobase, resulting in 2000 bins. A lowess curve with smoothing span of 0.1 is plotted in solid black. The line at 0.001 on the ordinate reflects the proportion of SNP that would be expected under the null hypothesis of no association. The red data points denote the 50 kb window considered for our primary association studies.