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. 2010 Sep 14;19(23):4663–4676. doi: 10.1093/hmg/ddq397

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© The Author 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — PCP pathway components are expressed in E18.5 kidney. Immunostaining (brown) for Scrib (A, C and E) and Celsr1 (B, D and F) in E18.5 sections (note there is no counterstain in these sections). Scrib expression was prominent in the outer (nephrogenic) cortex (c in A) where it was found in diverse structures such as ureteric bud tips, mesenchymal condensates and vesicles (C). Scrib was also expressed in maturing podocytes located in the periphery of the glomerular tuft (E). Celsr1 expression was noted in collecting duct stalks and S-shaped bodies just below the nephrogenic zone (B and D). Expression of Celsr1 was also observed in proximal tubule and podocyte epithelia (F). Where primary antibodies were omitted, no significant staining was observed (G and H). Dashed line in (G) marks edge of kidney; below line is tissue. c, cortex; g, glomerulus; m, medulla; pt, proximal tubule. Scale bars: (A and B) 100 μm, (C and D), (G) 25 μm and (E, F and H) 12.5 μm.