Table 1. Mean % antibody depletion from DiCo 1, 2 and 3-coated plates.
| Capture antigen | Competitor antigen | Gp 1 (7Ag/HT) n = 9 | Gp 2 (3Ag/HT) n = 8 | Gp 3 (3Ag/IMS) n = 8 | Gp 4 (3Ag/ISA 51) n = 5 |
| DiCo 1 | FVO | 84.7(81.6–87.8) | 83.0(79.5–86.6) | 77.0(71.9–82.0) | 77.4(73.0–81.8) |
| HB3 | 93.9(91.7–96.1) | 90.1(88.5–91.6) | 90.7(87.9–93.6) | 83.4(76.7–90.1) | |
| DM | 96.1(93.9–98.3) | 98.6(98.2–99.1) | 97.2(95.9–98.4) | 91.9(88.3–95.5) | |
| CAMP | 87.6(84.2–90.9) | 86.3(84.5–88.0) | 78.3(74.5–82.1) | 77.4(71.4–83.5) | |
| 3D7 | 75.2(72.2–78.2) | 76.9(73.1–80.8) | 69.3(65.0–73.6) | 61.4(54.9–68.0) | |
| NM | 97.6(96.1–99.0) | 92.4(91.3–93.4) | 92.1(90.8–93.5) | 88.2(85.8–90.6) | |
| DiCo 2 | FVO | 90.0(87.2–92.8) | 86.4(84.2–88.6) | 84.8(79.4–90.2) | 83.6(81.2–86.1) |
| HB3 | 94.0(91.8–96.2) | 94.4(91.1–97.8) | 97.1(94.8–99.4) | 83.7(71.6–95.7) | |
| DM | 96.1(93.9–98.4) | 97.6(96.4–98.9) | 98.1(96.6–99.6) | 92.9(90.4–95.5) | |
| CAMP | 83.0(79.6–86.4) | 83.5(80.1–87.0) | 77.9(75.3–80.5) | 77.3(76.1–78.6) | |
| 3D7 | 67.6(63.3–71.9) | 68.3(65.9–70.6) | 63.6(58.7–68.5) | 56.6(48.3–64.9) | |
| NM | 95.0(93.7–96.4) | 92.9(91.2–94.7) | 95.0(92.2–97.8) | 88.9(85.5–92.3) | |
| DiCo 3 | FVO | 81.2(77.7–84.6) | 81.9(78.2–85.6) | 72.8(66.9–78.7) | 74.1(66.8–81.4) |
| HB3 | 91.9(89.6–94.3) | 87.1(85.2–88.9) | 85.1(82.5–87.7) | 80.9(74.8–87.0) | |
| DM | 97.3(92.2–102.2) | 97.8(96.4–99.3) | 96.8(95.4–98.2) | 91.0(89.1–92.9) | |
| CAMP | 80.2(77.0–83.3) | 80.8(76.7–84.9) | 66.3(59.7–73.0) | 67.8(62.5–73.1) | |
| 3D7 | 82.1(78.6–85.6) | 80.6(77.9–83.2) | 66.5(61.4–71.7) | 57.8(47.9–67.6) | |
| NM | 94.2(93.1–95.4) | 91.4(89.0–93.7) | 86.5(83.6–89.4) | 84.0(77.6–90.4) |
Antibody depletion after competition ELISA, values reported as mean % depletion (95%CI).
7Ag – vaccine containing DiCo mix + four AMA1 alleles from FVO, HB3, 3D7 and CAMP parasite strains.
3Ag – vaccine containing DiCo mix.
NM &DM – competitor antigen mixtures comprising natural AMA1 alleles (FVO, HB3, 3D7, CAMP) and DiCo mix, respectively.