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. 2010 Oct 11;107(43):18593–18598. doi: 10.1073/pnas.1005582107

Fig. 1.

Fig. 1.

DNAM-1 expression on donor CD8+ T cells is involved in exacerbation of acute GVHD. (A) After sublethal irradiation, B6C3F1 mice received splenocytes from DNAM-1 WT (n = 14) or KO B6 (n = 16) mice. B6C3F1 mice that received irradiation only are also shown (n = 5). Data are representative of two independent experiments. (B) After sublethal irradiation, B6C3F1 recipient mice received TCD-SP plus CD8+ T cells from DNAM-1 WT or KO B6 mice and CD4+ T cells from DNAM-1 WT or KO B6 mice (n = 10 in each group). Data are pooled from two independent experiments. (C) After sublethal irradiation, DNAM-1 WT (n = 9) or KO (n = 18) CBF1 mice received splenocytes from DNAM-1 WT B6 mice. DNAM-1 WT and KO CBF1 mice that received irradiation alone are also shown (n = 5 and 7, respectively). The experiments were independently performed four times and pooled data from all of the experiments are shown.