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Structure-based multiple sequence alignment of human E2s. (Upper) Confirmed BRCA1-interacting E2s. (Lower) Non-BRCA1 interacting E2s. Sequences are shown only for E2 elements referred to as helix-1, loop L1 and loop L2, which are commonly found to interact with E3s. Ubiquitin transfer properties for E2s functioning in conjunction with BRCA1 are listed. The ubiquitin-like molecule used by each E2 is listed for non-BRCA1-interacting E2s.
