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. Author manuscript; available in PMC: 2010 Nov 4.
Published in final edited form as: Mol Microbiol. 2009 Aug 4;74(1):29–43. doi: 10.1111/j.1365-2958.2009.06831.x

Figure 8. Schematic diagram illustrating GlpR-mediated control of (right) glpFK transcription and (left) the rate of IS5 hopping (directed mutation) into the CTAA site upstream of the glpFK promoter.

Figure 8

With GlpR bound to its operators (O1–O4), transcription and IS5 hopping both occur at low rates. When GlpR is not bound to its operators, both transcriptional initiation and IS5 hopping increase about 10x. Binding of GlpR to operator O1 blocks IS5 insertion, while binding of GlpR to operator O4 blocks transcription as indicated.