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. 1968 Oct;47(10):2206–2216. doi: 10.1172/JCI105906

Erythrocytes in human transplantation: effects of pretreatment with ABO group-specific antigens

F T Rapaport 1,2, J Dausset 1,2, L Legrand 1,2, A Barge 1,2, H S Lawrence 1,2, J M Converse 1,2
PMCID: PMC297385  PMID: 4877681

Abstract

Erythrocyte group antigens A and B can act as potent and group-specific transplantation antigens in man. ABO group-incompatible recipients pretreated with such antigens have rejected skin allografts obtained from donors incompatible for the same antigens in an accelerated (4-5 days) or white graft manner. Skin grafts applied to the same recipients from ABO-compatible donors were accorded first-set survival times. Intact erythrocyte suspensions and antigens isolated from hog (A substance) and horse (B substance) stomachs, were equally capable of inducing this type of allograft sensitivity. The latter observation broadens the spectrum of heterologous antigens capable of inducing allograft sensitivity in the mammalian host and provides a readily available, heat-stable, and water-soluble source of antigens for further studies of allograft rejection mechanisms in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAER H., KABAT E. A., KNAUB V. Immuno-chemical studies on blood groups; the preparation of blood group A and B substances and an inactive substance from individual horse stomachs and of blood group B substance from human saliva. J Exp Med. 1950 Jan 1;91(1):105–114. doi: 10.1084/jem.91.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARRETT M. K., HANSEN W. H. Resistance to tumor implantation induced by red cell stromata. Cancer Res. 1953 Mar;13(3):269–275. [PubMed] [Google Scholar]
  3. BRENT L., MEDAWAR P. B., RUSZKIEWICZ M. Serological methods in the study of transplantation antigens. Br J Exp Pathol. 1961 Oct;42:464–477. [PMC free article] [PubMed] [Google Scholar]
  4. Brown J. B., McDowell F. EPITHELIAL HEALING AND THE TRANSPLANTATION OF SKIN. Ann Surg. 1942 Jun;115(6):1166–1181. doi: 10.1097/00000658-194206000-00027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CONVERSE J. M., RAPAPORT F. T. The vascularization of skin autografts and homografts; an experimental study in man. Ann Surg. 1956 Mar;143(3):306–315. doi: 10.1097/00000658-195603000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chase R. M., Jr, Rapaport F. T. The bacterial induction of homograft sensitivity. I. Effects of sensitization with group A streptococci. J Exp Med. 1965 Oct 1;122(4):721–732. doi: 10.1084/jem.122.4.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DAUSSET J., VIDAL G. Accidents de la transfusion chez des receveurs de groupe A ayant recu du sang de groupe O; rôle de la vaccination par l'anatoxine diphtérique et tétanique. Sang. 1951;22(6):478–489. [PubMed] [Google Scholar]
  8. Dausset J., Rapaport F. T. Role of ABO erythrocyte groups in human histocompatibility reactions. Nature. 1966 Jan 8;209(5019):209–211. doi: 10.1038/209209a0. [DOI] [PubMed] [Google Scholar]
  9. FUDENBERG H. H., KUNKEL H. G. Physical properties of the red cell agglutinins in acquired hemolytic anemia. J Exp Med. 1957 Nov 1;106(5):689–702. doi: 10.1084/jem.106.5.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GOODWIN W. E., MIMS M. M., KAUFMAN J. J. Human renal transplantation. III. Technical problems encountered in six cases of kidney homotransplantation. J Urol. 1963 Mar;89:349–356. doi: 10.1016/S0022-5347(17)64556-7. [DOI] [PubMed] [Google Scholar]
  11. GRIFFITHS C. O., Jr, CRIKELAIR G. F. Iso-immunization following skin homografting in man. Nature. 1962 Jan 13;193:186–188. doi: 10.1038/193186b0. [DOI] [PubMed] [Google Scholar]
  12. HAMBURGER J., VAYSSE J., CROSNIER J., AUVERT J., DORMONT J. Kidney homotransplantation in man. Ann N Y Acad Sci. 1962 Oct 24;99:808–820. doi: 10.1111/j.1749-6632.1962.tb45364.x. [DOI] [PubMed] [Google Scholar]
  13. HUME D. M., MAGEE J. H., KAUFFMAN H. M., Jr, RITTENBURY M. S., PROUT G. R., Jr RENAL HOMOTRANSPLANTATION IN MAN IN MODIFIED RECIPIENTS. Ann Surg. 1963 Oct;158:608–644. doi: 10.1097/00000658-196310000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HUME D. M., MERRILL J. P., MILLER B. F., THORN G. W. Experiences with renal homotransplantation in the human: report of nine cases. J Clin Invest. 1955 Feb;34(2):327–382. doi: 10.1172/JCI103085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. JACOBSON E., Jr, NAJARIAN J. S. ROLE OF THE RED BLOOD CELL ANTIGENS IN HOMOGRAFT REJECTION. Surg Forum. 1964;15:138–139. [PubMed] [Google Scholar]
  16. KUHNS W. J., RAPAPORT F. T., LAWRENCE H. S., CONVERSE J. M. SERUM ANTIBODY RESPONSE TO TISSUE TRANSPLANTATION ANTIGENS IN MAN. Ann N Y Acad Sci. 1964 Nov 30;120:36–45. doi: 10.1111/j.1749-6632.1964.tb34705.x. [DOI] [PubMed] [Google Scholar]
  17. LAWRENCE H. S., RAPAPORT F. T., CONVERSE J. M., TILLETT W. S. Transfer of delayed hypersensitivity to skin homografts with leukocyte extracts in man. J Clin Invest. 1960 Jan;39:185–198. doi: 10.1172/JCI104018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MURRAY J. E., HARRISON J. H. Surgical management of fifty patients with kidney transplants including eighteen pairs of twins. Am J Surg. 1963 Feb;105:205–218. doi: 10.1016/0002-9610(63)90292-7. [DOI] [PubMed] [Google Scholar]
  19. RAPAPORT F. T., CHASE R. M., Jr HOMOGRAFT SENSITIVITY INDUCTION BY GROUP A STREPTOCOCCI. Science. 1964 Jul 24;145(3630):407–408. doi: 10.1126/science.145.3630.407. [DOI] [PubMed] [Google Scholar]
  20. RAPAPORT F. T., CONVERSE J. M. Observations on immunological manifestations of the homograft rejection phenomenon in man: the recall flare. Ann N Y Acad Sci. 1957 Mar 22;64(5):836–841. doi: 10.1111/j.1749-6632.1957.tb52477.x. [DOI] [PubMed] [Google Scholar]
  21. RAPAPORT F. T., CONVERSE J. M. The immune response to multiple-set skin homografts: an experimental study in man. Ann Surg. 1958 Mar;147(3):273–280. doi: 10.1097/00000658-195803000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. RAPAPORT F. T., DAUSSET J., CONVERSE J. M., LAWRENCE H. S. BIOLOGICAL AND ULTRASTRUCTURAL STUDIES OF LEUCOCYTE FRACTIONS AS TRANSPLANTATION ANTIGENS IN MAN. Transplantation. 1965 Jul;3:490–500. doi: 10.1097/00007890-196507000-00004. [DOI] [PubMed] [Google Scholar]
  23. RAPAPORT F. T., LAWRENCE H. S., CONVERSE J. M., MULHOLLAND J. H. HOMOGRAFT ANTIGEN STUDIES IN MAN. Ann N Y Acad Sci. 1964 Nov 30;120:280–284. doi: 10.1111/j.1749-6632.1964.tb34726.x. [DOI] [PubMed] [Google Scholar]
  24. RAPAPORT F. T., LAWRENCE H. S., THOMAS L., CONVERSE J. M., TILLETT W. S., MULHOLLAND J. H. Cross-reactions to skin homografts in man. J Clin Invest. 1962 Dec;41:2166–2172. doi: 10.1172/JCI104675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. RAPAPORT F. T., THOMAS L., CONVERSE J. M., LAWRENCE H. S. The specificity of skin homograft rejection in man. Ann N Y Acad Sci. 1960 May 31;87:217–222. doi: 10.1111/j.1749-6632.1960.tb23195.x. [DOI] [PubMed] [Google Scholar]
  26. ROGERS B. O. The genetics of skin homotransplantation in the human. Ann N Y Acad Sci. 1957 Mar 22;64(5):741–766. doi: 10.1111/j.1749-6632.1957.tb52470.x. [DOI] [PubMed] [Google Scholar]
  27. Rapaport F. T., Chase R. M., Jr The bacterial induction of homograft sensitivity. II. Effects of sensitization with staphylococci and other microoorganisms. J Exp Med. 1965 Oct 1;122(4):733–744. doi: 10.1084/jem.122.4.733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rapaport F. T., Dausset J., Hamburger J., Hume D. M., Dano K., Williams G. M., Milgrom F. Serologic factors in human transplantation. Ann Surg. 1967 Oct;166(4):596–608. doi: 10.1097/00000658-196710000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
  30. SIMONSEN M., BUEMANN J., GAMMELTOFT A., JENSEN F., JORGENSEN K. Biological incompatibility in kidney transplantation in dogs. I. Experimental and morphological investigations. Acta Pathol Microbiol Scand. 1953;32(1):1–35. doi: 10.1111/j.1699-0463.1953.tb00229.x. [DOI] [PubMed] [Google Scholar]
  31. SIMONSEN M., SØRENSEN F. Homoplastic kidney transplantation in dogs. Acta Chir Scand. 1949 Oct 31;99(1):61–72. [PubMed] [Google Scholar]
  32. STARZL T. E., MARCHIORO T. L., HERMANN G., BRITTAIN R. S., WADDELL W. R. RENAL HOMOGRAFTS IN PATIENTS WITH MAJOR DONOR-RECIPIENT BLOOD GROUP INCOMPATIBILITIES. Surg Forum. 1963;14:214–216. [PMC free article] [PubMed] [Google Scholar]
  33. STARZL T. E., MARCHIORO T. L., HOLMES J. H., HERMANN G., BRITTAIN R. S., STONINGTON O. H., TALMAGE D. W., WADDELL W. R. RENAL HOMOGRAFTS IN PATIENTS WITH MAJOR DONOR-RECIPIENT BLOOD GROUP INCOMPATIBILITIES. Surgery. 1964 Feb;55:195–200. [PMC free article] [PubMed] [Google Scholar]
  34. STARZL T. E., MARCHIORO T. L., HOLMES J. H., WADDELL W. R. THE INCIDENCE, CAUSE, AND SIGNIFICANCE OF IMMEDIATE AND DELAYED OLIGURIA OR ANURIA AFTER HUMAN RENAL TRANSPLANTATION. Surg Gynecol Obstet. 1964 Apr;118:819–827. [PMC free article] [PubMed] [Google Scholar]
  35. WOODRUFF M. F. A., ALLAN T. M. Blood groups and the homograft problem. Br J Plast Surg. 1953 Jan;5(4):238–242. doi: 10.1016/s0007-1226(53)80050-0. [DOI] [PubMed] [Google Scholar]

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