Table 1.

Non–BM-derived cells mediate Bphs

Donor	Recipient	No PTX	PTX	P value
C3H/HeJ	C3H/HeJ	0/2	0/4
BphsS	BphsS	0/2	7/8	0.004
BphsS	C3H/HeJ	0/2	2/10
C3H/HeJ	BphsS	0/2	9/10	0.002
Het	Het	0/2	6/7	0.006
Het	C3H/HeJ	0/2	1/6
C3H/HeJ	Het	0/2	6/6	0.007

Reciprocal BM chimeras using C3H/HeJ, C3H.Bphs^SJL/J (Bphs^S), or heterozygous C3H/HeJ × C3H.Bphs^SJL/J F₁ hybrid (Het) mice were generated as described in Materials and Methods. After reconstitution, mice were injected i.v. with 200 ng of PTX, and 3 d later, they were challenged i.v. with histamine (12.5, 6.25, 3.125, and 1.56 mg/kg of histamine). The data are the total number of animals that died within 30 min divided by the total number of animals studied at all doses. Control mice received carrier alone on day 0 and were challenged with 12.5 mg/kg of histamine 3 d later. A χ² test was used to detect the significance of differences.