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The secondary structure of human telomerase RNA (hTR) (Upper) and the sequence and secondary structure of the hTR core domain with helical and loop regions labeled (Lower). The hTERT (gray ellipse) interacts with both the hTR core and hTR CR4/CR5 domains. The P2/P3 pseudoknot contains three subdomains: P2a.1-J2a.1-P2a (P2a1a) [colored blue-black-gold], P2a-J2a/b-P2b (P2ab) [colored gold-green-red], and the P2b-P3 pseudoknot [colored red-pink].
