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. 2010 Nov 4;5(11):e13844. doi: 10.1371/journal.pone.0013844

Figure 1. Identification of uORFs in TU-1A and TU-1B.

Figure 1

A) The upper panel contains a schematic representation of the SHBG gene. Coding exons are shown in black boxes and noncoding alternative first exons are in gray boxes, with their respective sizes (in bp) indicated above. Below are depicted the exon organization of mature mRNAs of TU-1A and 1B and the corresponding ORF organization. uAUGs (AUG1 and 2) are written in gray while SHBG AUG is written in black (AUG3). uORFs are indicated in gray boxes while SHBG ORF is shown in a black box. AUG1 generates an uORF of 2 codons while AUG2 generates an uORF of 11 codons. B). Exon 2 scheme, showing AUG2 and 3. AUG2 starts a uORF whose stop codon overlaps the SHBG translation start codon (AUG3).