Figure 5. Targeted inhibition of MEK1/2 inhibits HNSCC cell motility.
1483 and UMSCC1 cells (5×105) were starved for 24 h in the presence of vehicle (DMSO) or increasing concentrations of selumetinib as indicated. Cells were assayed for motility by electric substrate impedance sensing (ECIS) following stimulation with complete media containing the matched selumetinib concentration for 24 h. Data is displayed as slope values calculated from the linear part of ECIS tracings. Bars represent mean ± SE. *, p<0.05 compared to DMSO treated control cells.