Table 3.
Polyphenols and microRNAs
| Dietary agent | Plant source | Analysis Method | Micro RNAs | Target gene | In vitro model | In vivo model | Concentration | Treatment duration |
References |
|---|---|---|---|---|---|---|---|---|---|
| 3,3-diindolylmethane | Broccoli | Microarray; qRT-PCR | miR-200 (a–c), let-7 (a– f), miR-146a |
ZEB1, EGFR | Pancreas | 25 µM | 48h | (225; 226) | |
| Curcumin | Turmeric | Microarray; qRT-PCR | miR-22, miR-199a*, miR-21, miR-200 |
SP1, ESR1, PTEN |
Pancreas | 1–10 µM | 72h | (222; 223) | |
|
Epigalocatechin-3- gallate |
Green tea | Microarray; qRT-PCR | miR-16 | BCLl2 | Liver | 100 µM | 24h | (224) | |
|
Genistein (with diadzein, glycetein) |
Soy | Microarray; qRT-PCR | miR-200 (a–c), let-7 (a– f), mir-27b, miR-146a |
ZEB1, ZBTB10, EGFR |
Pancreas; Uveal; Melanoma; Ovarian |
25 µM | 48h | (225–228) | |
| Isothiocyanates | Broccoli, wasabi | Microarray | Rat: lung cancer | 500 mg/kg | 28d | (229) |