Fig 1.

Soman increases COX-2 expression in brain. Rats (N= 5 per group) were treated with soman and brains were processed for immunohistochemistry at the indicated times after treatment using antibodies against COX-2 as described in Materials and Methods. COX-2 positive cells were counted in dentate gyrus (A), CA3 (B), amygdala (C) and piriform cortex (D). Very few COX-2 positive cells were seen from 0-12 hours after soman so these data are not shown. Results are presented as number of COX-2 positive cells in each brain region ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001, Tukey's multiple comparison test by comparison to controls.