Fig 2.

Soman increases COX-2 expression in the hippocampus. Rats (N= 5 per group) were treated with soman and brains were prepared for immunohistochemistry 48 hr after treatment using antibodies against COX-2. Few COX-2 positive cells are seen in controls (A) whereas the dentate gyrus, CA1 and CA3 are heavily labeled with COX-2 after soman treatment (B). Higher magnification images of the dentate gyrus shows sparse labeling of cells in controls (C) and densely packed COX-2-positive cells in soman-treated rats (D). Similarly, higher magnification images from the CA3 region of controls shows few COX-2-positive cells in controls (E) whereas soman treatment causes a large increase in COX-2 levels (F).