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Soman increases COX-2 expression in the piriform cortex and amygdala. Rats (N= 5 per group) were treated with soman and brains were prepared for immunohistochemistry 48 hr after treatment using antibodies against COX-2. Few COX-2 positive cells are seen in the piriform cortex of controls (A) whereas numerous cells and processes are COX-2 positive after soman treatment (B). Soman also leads to large increases in COX-2 expression in the amygdala (D) as compared to controls (C).
