Fig 4.

Soman does not change COX-1 expression in brain. Rats (N= 5 per group) were treated with soman and brains were processed for immunohistochemistry 48 hr after treatment using antibodies against COX-1 as described in Materials and Methods. Few COX-1 positive cells are seen in the hippocampus of controls (A) or soman (B) treated rats at low power magnification. Images collected from the amygdala at higher magnification showed numerous COX-1 positive cells in controls (C) but soman treatment (D) did not increase the number of these cells.