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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Neurotoxicology. 2010 Jul 1;31(6):738–746. doi: 10.1016/j.neuro.2010.06.007

Fig 5.

Fig 5

Soman-induced increases in COX-2 expression are correlated with seizure intensity. Rats (N= 5-8 per group) were treated with soman and scored behaviorally for seizure intensity 1 hr after treatment as described in Materials and Methods. At 48 hr after soman, brains were processed for immunoblotting for COX-2 and COX-1 in the hippocampus. Panel A shows immunoblotting results for COX-2 and COX-1 from controls (C) and soman treated rats (S). The fold-increase in COX-2 (■) and COX-1 (○) expression caused by soman was plotted versus seizure intensity in panel B. The relationship between changes in COX-2 levels and seizure intensity was significant (r=0.73, p < 0.0001). COX-1 levels were not changed by soman treatment.

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