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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Nat Nanotechnol. 2010 Oct 10;5(11):778–782. doi: 10.1038/nnano.2010.190

Figure 1.

Figure 1

Overview of the DNAsome system. (a) The system described in this work comprises six DNA or DNA-linked molecules. Three substrates (S1-S3) and an initiator (S0) can hybridize on a single-stranded DNA track (T). Each substrate has an amino acid NHS ester at its 5’ end and two ribonucleotides (green dot) in the middle of its DNA sequence. The DNA walker (W) contains a 3’ amine group and an RNA-cleaving DNAzyme (purple line) that can cleave the ribonucleotides in the substrates. (b) DNAsome-mediated multistep synthesis of a triamide product. All steps take place in a single solution under one set of reaction conditions without external intervention.